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研究成果 (論文)

Jan 23, 2024

Original Research

International Immunology

A purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations

Hiroaki Shiratori, Kisara M Hattori, Kazuaki Nakata, Takuma Okawa, Seiga Komiyama, Yusuke Kinashi, Yuma Kabumoto, Yuria Kaneko, Motoyoshi Nagai, Tomoko Shindo, Nobuko Moritoki, Yuki I Kawamura, Taeko Dohi, Daisuke Takahashi, Shunsuke Kimura, Koji Hase* (*corresponding author)



Nov 5, 2023

Original Research

Biomaterials

Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles

Shunyi Li†, Hiroki Toriumi†, Daisuke Takahashi, Tomoko Kamasaki, Yoichiro Fujioka, Satoru Nagatoishi, Jinting Li, Yiwei Liu, Takanatsu Hosokawa, Kouhei Tsumoto, Yusuke Ohba, Yoshiki Katayama, Daisuke Murakami, Koji Hase, Takeshi Mori (†equal first author; *corresponding author)



Nov 1, 2023

Original Research

Frontiers in immunology

α-Glucosidase inhibitors boost gut immunity by inducing IgA responses in Peyer’s patches

Kisara Hattori-Muroi, Hanako Naganawa-Asaoka, Yuma Kabumoto, Kei Tsukamoto, Yosuke Fujisaki, Yumiko Fujimura, Seiga Komiyama, Yusuke Kinashi, Miki Kato, Shintaro Sato, Daisuke Takahashi*, Koji Hase*(*corresponding author)



Aug 1, 2023

Review

腸内細菌学雑誌

Immune Imprinting by Gut Microbiota Early in Life, a Window of Opportunity

Koichiro Suzuki, Koji Hase* (*corresponding author)



Jun 1, 2023

Original Research

Scientific Reports

Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation

Hiroaki Shiratori†, Hiroyuki Oguchi†, Yosuke Isobe†, Kyu-Ho Han, Akira Sen, Kyosuke Yakebe, Daisuke Takahashi, Michihiro Fukushima, Makoto Arita*, Koji Hase* (†equal first author; *corresponding author)



Apr 3, 2023

Original Research

Scientific Reports

Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells

Yutaka Nakamura, Yozen Fuse, Seiga Komiyama, Takahiro Nagatake, Jun Kunisawa, Koji Hase* (*corresponding author)



Oct 6, 2022

Original Research

Frontiers in Allergy

Spi-B alleviates food allergy by securing mucosal barrier and immune tolerance in the intestine. Frontiers in Allergy

Narumi Ishihara, Yutaka Nakamura, Kyosuke Yakabe, Seiga Komiyama, Yumiko Fujimura, Tsuneyasu Kaisho, Shunsuke Kimura, Koji Hase* (*corresponding author)



Sep 1, 2022

Original Research

Biological & pharmaceutical bulletin

A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production

Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase*, Daisuke Takahashi* (*corresponding author)



Jul 29, 2022

Original Research

Science Immunology

Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection

Goo-Young Seo†, Daisuke Takahashi†, Qingyang Wang, Zbigniew Mikulski, Angeline Chen, Ting-Fang Chou, Paola Marcovecchio, Sara McArdle, Ashu Sethi, Jr-Wen Shui, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg* (†equal first author; *corresponding author)



Nov 22, 2021

Original Research

Frontiers in Immunology

Characterization of M Cells in Tear Duct-Associated Lymphoid Tissue of Mice: A Potential Role in Immunosurveillance on the Ocular Surface

Yuki Oya, Shunsuke Kimura, Yutaka Nakamura, Narumi Ishihara, Shunsuke Takano, Ryo Morita, Mayumi Endo, Koji Hase



Sep 16, 2021

Original Research

Microbiome

Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

Ryo Aoki, Masayoshi Onuki, Koya Hattori, Masato Ito, Takahiro Yamada, Kohei Kamikado, Yun-Gi Kim, Nobuhiro Nakamoto, Ikuo Kimura, Julie M. Clarke, Takanori Kanai, Koji Hase



Aug 12, 2021

Original Research

Frontiers in Pharmacology

A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice

Ryohtaroh Matsumoto, Daisuke Takahashi, Masaki Watanabe, Shunsuke Nakatani, Yuta Takamura, Yuji Kurosaki, Hiroki Kakuta, Koji Hase*



Aug 10, 2021

Review

International immunology

Intestinal immunity: to be, or not to be, induced? That is the question

Daisuke Takahashi†, Shunsuke Kimura†, Koji Hase



May 19, 2021

Original Research

Scientific reports

Profiling of tumour-associated microbiota in human hepatocellular carcinoma

Seiga Komiyama, Takahiro Yamada, Nobuyuki Takemura, Norihiro Kokudo, Koji Hase, Yuki I Kawamura



Apr 22, 2021

Review

Frontiers in immunology

Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity

Yusuke Kinashi, Koji Hase*



Apr 8, 2021

Original Research

Nature Communications

Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase



Feb 4, 2021

Review

Frontiers in Immunology

Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic Rewiring

Takuma Okawa, Motoyoshi Nagai, Koji Hase


Sep 15, 2020

Original Research

Archives of Biochemistry and Biophysics

Polyamines polarized Th2/Th9 cell-fate decision by regulating GATA3 expression

Nakamura A, Takahashi D, Nakamura Y, Yamada T, Matsumoto M, Hase K


Jun 23, 2020

Original Research

EBioMedicine

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

Daisuke Takahashi †, Naomi Hoshina †, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, Yumiko Fujimura, Aiko Saeki, Mizuki Ueda, Ryohtaroh Matsumoto, Hanako Asaoka, Julie M. Clarke, Yohsuke Harada, Eiji Umemoto, Noriko Komatsu, Takaharu Okada, Hiroshi Takayanagi, Kiyoshi Takeda, Michio Tomura, Koji Hase



Feb 28, 2020

Original Research

Science

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

Ikuo Kimura, Junki Miyamoto, Ryuji Ohue-Kitano, Keita Watanabe, Takahiro Yamada, Masayoshi Onuki, Ryo Aoki, Yosuke Isobe, Daiji Kashihara, Daisuke Inoue, Akihiko Inaba, Yuta Takamura, Satsuki Taira, Shunsuke Kumaki, Masaki Watanabe, Masato Ito, Fumiyuki Nakagawa, Junichiro Irie, Hiroki Kakuta, Masakazu Shinohara, Ken Iwatsuki, Gozoh Tsujimoto, Hiroaki Ohno, Makoto Arita, Hiroshi Itoh, Koji Hase


Jan 13, 2020

Original Research

Nature Communications

Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity

Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, Nobuyuki Udagawa, Shintaro Sato, Tsuneyasu Kaisho, Toshihiko Iwanaga & Koji Hase 



Dec 20, 2019

Original Research

International Immunology

Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon

Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi, Koji Hase



Oct 9, 2019

Review

Frontiers in immunology

The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

Nobuhide Kobayashi, Daisuke Takahashi, Shunsuke Takano, Shunsuke Kimura, Koji Hase



Sep 11, 2019

Original Research

EBioMedicine

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Takahiro Yamada, Shingo Hino, Hideki Iijima, Tomomi Genda, Ryo Aoki, Ryuji Nagata, Kyu-Ho Han, Masato Hirota, Yusuke Kinashi, Hiroyuki Oguchi, Wataru Suda, Yukihiro Furusawa, Yumiko Fujimura, Jun Kunisawa, Masahira Hattori, Michihiro Fukushima, Tatsuya Morita, Koji Hase



Aug 22, 2019

Original Research

Cell

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Motoyoshi Nagai, Ryotaro Noguchi, Daisuke Takahashi, Takayuki Morikawa, Kouhei Koshida, Seiga Komiyama, Narumi Ishihara, Takahiro Yamada, Yuki I. Kawamura, Kisara Muroi, Kouya Hattori, Nobuhide Kobayashi, Yumiko Fujimura, Masato Hirota, Ryohtaroh Matsumoto, Ryo Aoki, Miwa Tamura-Nakano, Machiko Sugiyama, Tomoya Katakai, Shintaro Sato, Keiyo Takubo, Taeko Dohi, Koji Hase



Mar 15, 2019

Original Research

The Journal of Experimental Medicine

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Shunsuke Kimura, Nobuhide Kobayashi, Yutaka Nakamura, Takashi Kanaya, Daisuke Takahashi, Ryoji Fujiki, Mami Mutoh, Yuuki Obata, Toshihiko Iwanaga, Tomoo Nakagawa, Naoya Kato, Shintaro Sato, Tsuneyasu Kaisho, Hiroshi Ohno, Koji Hase



Dec 26, 2018

Original Research

International Immunology

A partial agonist for retinoid X receptor mitigates experimental colitis

Masayoshi Onuki, Masaki Watanabe, Narumi Ishihara, Koichiro Suzuki, Kei Takizawa, Masato Hirota, Takahiro Yamada, Aiko Egawa, Osamu Shibahara, Midori Nishii, Michiko Fujihara, Makoto Makishima, Daisuke Takahashi, Yukihiro Furusawa, Hiroki Kakuta, Koji Hase



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