top of page
慶應義塾大学
薬学部生化学講座
研究成果 (論文)
2026年1月30日
Original Research
International Immunology
Identification and characterization of CXCL13 producers in bone tissue in response to fasting
Takuma Okawa , Motoyoshi Nagai , Shinya Fujita , Koichiro Suzuki , Kazuaki Nakata , Reina Miyajima , Hiroaki Shiratori , Seiga Komiyama , Daisuke Takahashi , Yuki I Kawamura , Taeko Dohi , Burkhard Ludewig , Keiyo Takubo , Koji Hase
2026年1月9日
Original Research
Proceedings of the National Academy of Sciences of the United States of America
M cell–dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer’s patches
Seiga Komiyama, Yotaro Kodaira, Rae Maeda, Yuki Sugiura, Koichiro Suzuki, Aiko Saeki, Yusuke Kinashi, Hiroyuki Oguchi, Kokona Takano, Satoshi Onawa, Ako Matsui, Eita Sasaki, Kisara Hattori-Muroi, Shunsuke Kimura, Yumiko Fujimura, Yuyo Ka, Tomoyuki Ogura, Kenjiro Hanaoka, Minako Ito, Hiroshi Watarai, Tsuneyasu Kaisho, Nobuyuki Udagawa, Daisuke Takahashi, and Koji Hase
2025年8月15日
Original Research
bioRxiv
Dietary soy shapes murine microbiota to consolidate the mucosal IgA response through T follicular helper cells
Kisara Hattori-Muroi, Hikari Maruta, Daisuke Takahashi, Yusuke Kinashi, Kouya Hattori, Yuma Kabumoto, Yumiko Fujimura, Satoshi Tsukamoto, Koichiro Suzuki, Hiroyuki Oguchi, Yumi Ogihara, Yotaro Kodaira, Emi Hayashi, Kokona Takano, Seiga Komiyama, Naoki Morita, Hanako Naganawa-Asaoka, Yuki Oya, Yuka Saito, Wakana Ohhashi, Shunsuke Kimura, Reiko Shinkura, Tsukasa Matsuda, Koji Hase
2024年10月5日
Original Research
Cellular and Molecular Life Sciences
AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine.
Ryohtaroh Matsumoto, Kosuke Ogata, Daisuke Takahashi, Yusuke Kinashi, Takahiro Yamada, Ryo Morita, Keisuke Tanaka, Kouya Hattori, Mayumi Endo, Yumiko Fujimura, Nobuo Sasaki, Hiroshi Ohno, Yasushi Ishihama, Shunsuke Kimura, Koji Hase
2024年7月25日
Original Research
EBioMedicine
Intestinal epithelium dysfunctions cause IgA deposition in the
kidney glomeruli of intestine-specific Ap1m2-deficient mice
Yusuke Kinashi, Keisuke Tanaka, Shunsuke Kimura, Masato Hirota, Seiga Komiyama, Tomoko Shindo, Akinori Hashiguchi, Daisuke Takahashi, Shinsuke Shibata, Shin-Ichiro Karaki, Hiroshi Ohno, Koji Hase
2024年7月23日
Original Research
Cell Reports
Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine
Motoyoshi Nagai, Takuma Okawa, Kazuaki Nakata, Daisuke Takahashi, Reina Miyajima, Hiroaki Shiratori,
Daisuke Yamanaka, Atsuo Nakamura, Chinatsu Oyama, Shin-Ichiro Takahashi, Noriko Toyama-Sorimachi, Koichiro Suzuki, Wakana Ohashi, Taeko Dohi, Yuki I. Kawamura, Koji Hase
2024年1月23日
Original Research
International Immunology
A purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations
Hiroaki Shiratori, Kisara M Hattori, Kazuaki Nakata, Takuma Okawa, Seiga Komiyama, Yusuke Kinashi, Yuma Kabumoto, Yuria Kaneko, Motoyoshi Nagai, Tomoko Shindo, Nobuko Moritoki, Yuki I Kawamura, Taeko Dohi, Daisuke Takahashi, Shunsuke Kimura, Koji Hase* (*corresponding author)
2023年11月5日
Original Research
Biomaterials
Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles
Shunyi Li†, Hiroki Toriumi†, Daisuke Takahashi, Tomoko Kamasaki, Yoichiro Fujioka, Satoru Nagatoishi, Jinting Li, Yiwei Liu, Takanatsu Hosokawa, Kouhei Tsumoto, Yusuke Ohba, Yoshiki Katayama, Daisuke Murakami, Koji Hase, Takeshi Mori (†equal first author; *corresponding author)
2023年11月1日
Original Research
Frontiers in immunology
α-Glucosidase inhibitors boost gut immunity by inducing IgA responses in Peyer’s patches
Kisara Hattori-Muroi, Hanako Naganawa-Asaoka, Yuma Kabumoto, Kei Tsukamoto, Yosuke Fujisaki, Yumiko Fujimura, Seiga Komiyama, Yusuke Kinashi, Miki Kato, Shintaro Sato, Daisuke Takahashi*, Koji Hase*(*corresponding author)
2023年6月1日
Original Research
Scientific Reports
Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation
Hiroaki Shiratori†, Hiroyuki Oguchi†, Yosuke Isobe†, Kyu-Ho Han, Akira Sen, Kyosuke Yakebe, Daisuke Takahashi, Michihiro Fukushima, Makoto Arita*, Koji Hase* (†equal first author; *corresponding author)
2022年10月6日
Original Research
Frontiers in Allergy
Spi-B alleviates food allergy by securing mucosal barrier and immune tolerance in the intestine. Frontiers in Allergy
Narumi Ishihara, Yutaka Nakamura, Kyosuke Yakabe, Seiga Komiyama, Yumiko Fujimura, Tsuneyasu Kaisho, Shunsuke Kimura, Koji Hase* (*corresponding author)
2022年9月1日
Original Research
Biological & pharmaceutical bulletin
A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production
Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase*, Daisuke Takahashi* (*corresponding author)
2022年7月29日
Original Research
Science Immunology
Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection
Goo-Young Seo†, Daisuke Takahashi†, Qingyang Wang, Zbigniew Mikulski, Angeline Chen, Ting-Fang Chou, Paola Marcovecchio, Sara McArdle, Ashu Sethi, Jr-Wen Shui, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg* (†equal first author; *corresponding author)
2021年11月22日
Original Research
Frontiers in Immunology
Characterization of M Cells in Tear Duct-Associated Lymphoid Tissue of Mice: A Potential Role in Immunosurveillance on the Ocular Surface
Yuki Oya, Shunsuke Kimura, Yutaka Nakamura, Narumi Ishihara, Shunsuke Takano, Ryo Morita, Mayumi Endo, Koji Hase
2021年9月16日
Original Research
Microbiome
Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice
Ryo Aoki, Masayoshi Onuki, Koya Hattori, Masato Ito, Takahiro Yamada, Kohei Kamikado, Yun-Gi Kim, Nobuhiro Nakamoto, Ikuo Kimura, Julie M. Clarke, Takanori Kanai, Koji Hase
2021年4月8日
Original Research
Nature Communications
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase
2020年6月23日
Original Research
EBioMedicine
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells
Daisuke Takahashi †, Naomi Hoshina †, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, Yumiko Fujimura, Aiko Saeki, Mizuki Ueda, Ryohtaroh Matsumoto, Hanako Asaoka, Julie M. Clarke, Yohsuke Harada, Eiji Umemoto, Noriko Komatsu, Takaharu Okada, Hiroshi Takayanagi, Kiyoshi Takeda, Michio Tomura, Koji Hase
2020年2月28日
Original Research
Science
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice
Ikuo Kimura, Junki Miyamoto, Ryuji Ohue-Kitano, Keita Watanabe, Takahiro Yamada, Masayoshi Onuki, Ryo Aoki, Yosuke Isobe, Daiji Kashihara, Daisuke Inoue, Akihiko Inaba, Yuta Takamura, Satsuki Taira, Shunsuke Kumaki, Masaki Watanabe, Masato Ito, Fumiyuki Nakagawa, Junichiro Irie, Hiroki Kakuta, Masakazu Shinohara, Ken Iwatsuki, Gozoh Tsujimoto, Hiroaki Ohno, Makoto Arita, Hiroshi Itoh, Koji Hase
2020年1月13日
Original Research
Nature Communications
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, Nobuyuki Udagawa, Shintaro Sato, Tsuneyasu Kaisho, Toshihiko Iwanaga & Koji Hase
2019年12月20日
Original Research
International Immunology
Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon
Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi, Koji Hase
2019年9月11日
Original Research
EBioMedicine
Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis
Takahiro Yamada, Shingo Hino, Hideki Iijima, Tomomi Genda, Ryo Aoki, Ryuji Nagata, Kyu-Ho Han, Masato Hirota, Yusuke Kinashi, Hiroyuki Oguchi, Wataru Suda, Yukihiro Furusawa, Yumiko Fujimura, Jun Kunisawa, Masahira Hattori, Michihiro Fukushima, Tatsuya Morita, Koji Hase
2019年8月22日
Original Research
Cell
Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses
Motoyoshi Nagai, Ryotaro Noguchi, Daisuke Takahashi, Takayuki Morikawa, Kouhei Koshida, Seiga Komiyama, Narumi Ishihara, Takahiro Yamada, Yuki I. Kawamura, Kisara Muroi, Kouya Hattori, Nobuhide Kobayashi, Yumiko Fujimura, Masato Hirota, Ryohtaroh Matsumoto, Ryo Aoki, Miwa Tamura-Nakano, Machiko Sugiyama, Tomoya Katakai, Shintaro Sato, Keiyo Takubo, Taeko Dohi, Koji Hase
2019年3月15日
Original Research
The Journal of Experimental Medicine
Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice
Shunsuke Kimura, Nobuhide Kobayashi, Yutaka Nakamura, Takashi Kanaya, Daisuke Takahashi, Ryoji Fujiki, Mami Mutoh, Yuuki Obata, Toshihiko Iwanaga, Tomoo Nakagawa, Naoya Kato, Shintaro Sato, Tsuneyasu Kaisho, Hiroshi Ohno, Koji Hase
2018年12月26日
Original Research
International Immunology
A partial agonist for retinoid X receptor mitigates experimental colitis
Masayoshi Onuki, Masaki Watanabe, Narumi Ishihara, Koichiro Suzuki, Kei Takizawa, Masato Hirota, Takahiro Yamada, Aiko Egawa, Osamu Shibahara, Midori Nishii, Michiko Fujihara, Makoto Makishima, Daisuke Takahashi, Yukihiro Furusawa, Hiroki Kakuta, Koji Hase
bottom of page